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THC activates the body’s "reward" pathways to produce the "high" that’s associated with marijuana use. It does this by activating a cannabinoid receptor called CB1. When THC activates this type of receptor, things like movement, body temperature, and brain function are affected. In contrast, CBD is not considered psychoactive. It does not cause euphoria or a "high," even at large doses.<br><br><br><br>Much of the research on CBD and THC is preclinical, meaning it’s been studied in animal models. Large-scale human trials are necessary to determine if CBD or THC can help treat most of these conditions. Though it does act on cannabinoid receptors, CBD mainly affects other receptors, including serotonin receptors. It may help counteract some of the negative effects of THC, including serious side effects like psychosis. CBD has many purported therapeutic properties. Pain. Overall, there isn’t enough evidence that CBD by itself helps with pain. 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