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The most effective medications improve core ADHD symptoms by affecting neurotransmitters, such as dopamine and norepinephrine. They function by increasing the availability of these neurotransmitters at the presynaptic transporters, and reducing their reuptake to avoid their breakdown. Since physicians cannot determine which medications will be the most effective for a particular person, they usually conduct a medication trial. The process begins with a low dose that is slowly increased over 3-7 days until the clinical benefits are realized.<br><br>Methylphenidate is one of the most commonly used psychostimulants that is used to treat ADHD. It is available in tablet form, liquid or extended-release form (Concerta). Extended-release is the most reliable because it cannot be crushed and used in other ways, like getting high. Adults who misuse stimulant medications are susceptible to serious health issues. 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